Penicillin and macrolides are often used in the modern antibacterial practice. These are two groups of the antibiotics which have a good tolerance, seldom cause side effects and have a broad spectrum action.

The most popular penicillin antibiotic is Amoxicillin, and the most popular macrolide is Azithromycin. These drugs are often compared between each other in order to find out a better action to the pathogenic microorganisms and what to use during the first infection symptoms.

First of all, it is necessary to detect an infection originator and a site of the infectious process during selecting an antibiotic. Antibiotics differently penetrate into the various tissues and biological liquids, and therefore it is better to select drugs which are accumulated in the tissues and penetrate well into the cells.

Azithromycin significantly differs from other antibiotics by its pharmacokinetics, and it is accumulated in high concentration in the tissues, cells, and has a long half-life. Unlike Amoxicillin, it is effective against intracellular pathogens.

Amoxicillin better works for the treatment of the airway infections. It can be also used during the inflammatory infections of HENT. This antibiotic is not good during the treatment of the sexual infections, infections of kidneys or bones, but it is rather often used in the medical practice. An infection originator and Amoxicillin dosage play an important role.

Azithromycin antibiotic is similarly effective during any infectious processes. Correctly adjusting the dose can provide a bacteriostatic or bactericidal action. The acid resistance of Azithromycin and Amoxicillin is approximately similar. These antibiotics can be used regardless of meals, food does not influence on the bioavalability of the active ingredients.

The pharmacological safety of Azithromycin and amoxicillin is also similar. These antibiotics seldom cause side effects, are well tolerated, and have minimal contraindications. Azithromycin has good characteristics of the microbial resistance. The microorganisms seldom produce resistance to the action of this medicine.

As any penicillin antibiotic, Amoxicillin may be ineffective because microorganisms have a resistance to its pharmacological action. But Amoxicillin can be used in cases when a patient has an individual intolerance of macrolides, or bacteria are resistant to erythromycin.

The advantage of Azithromycin before Amoxicillin is an application once per day. Usually, 3-4 days will be enough during infections of the middle severity to completely arrest the infection symptoms. The therapy dose of Azithromycin is 1,5-2 g.

Using Amoxicillin arrests the symptoms within 5-7 days, and the therapy dose is 7,5-10,5 g. It is a big difference, and therefore patients with dysfunctions of kidneys or liver should use Azithromycin in the treatment of the infectious diseases.

Amoxicillin vs Azithromycin: Conclusion

Comparing Amoxicillin vs Azithromycin, a leader is a macrolide antibiotic. It have been developed pater than penicillin antibiotics, and has more intense pharmacological action.

Azithromycin perfectly works for the treatment of any infectious processes and it can be used in the different combinations including with amoxicillin. Therefore doctors and many scientists recommend Azithromycin as the basic drug in the treatment of the bacterial infections.